How to cite item

The cardiac hypoxic niche: emerging role of hypoxic microenvironment in cardiac progenitors

   
@article{CDT1286,
	author = {Wataru Kimura and Hesham A. Sadek},
	title = {The cardiac hypoxic niche: emerging role of hypoxic microenvironment in cardiac progenitors},
	journal = {Cardiovascular Diagnosis and Therapy},
	volume = {2},
	number = {4},
	year = {2012},
	keywords = {},
	abstract = {Resident stem cells persist throughout the entire lifetime of an organism where they replenishing damaged cells. Numerous types of resident stem cells are housed in a low-oxygen tension (hypoxic) microenvironment, or niches, which seem to be critical for survival and maintenance of stem cells. Recently our group has identified the adult mammalian epicardium and subepicardium as a hypoxic niche for cardiac progenitor cells. Similar to hematopoietic stem cells (LT-HSCs), progenitor cells in the hypoxic epicardial niche utilize cytoplasmic glycolysis instead of mitochondrial oxidative phosphorylation, where hypoxia inducible factor 1α (Hif-1α) maintains them in glycolytic undifferentiated state. In this review we summarize the relationship between hypoxic signaling and stem cell function, and discuss potential roles of several cardiac stem/progenitor cells in cardiac homeostasis and regeneration.},
	issn = {2223-3660},	url = {https://cdt.amegroups.org/article/view/1286}
}