@article{CDT13292,
author = {Ahmad Masri and Mohamed Kanj and Maran Thamilarasan and Oussama Wazni and Nicholas G. Smedira and Harry M. Lever and Milind Y. Desai},
title = {Outcomes in hypertrophic cardiomyopathy patients with and without atrial fibrillation: a survival meta-analysis},
journal = {Cardiovascular Diagnosis and Therapy},
volume = {7},
number = {1},
year = {2017},
keywords = {},
abstract = {Background: Atrial fibrillation (AF) is a frequent occurrence in patients with hypertrophic cardiomyopathy (HCM). It is associated with worsening symptoms, cardiovascular events, and mortality. We conducted a meta-analysis of studies reporting on mortality in patient with HCM and AF.
Methods: We searched PubMed, Medline, Embase, Ovid and Cochrane for studies which reported cardiovascular events and mortality in patients with HCM and AF. Outcome was a composite of cardiac mortality and/or all-cause mortality. Mantel Haenszel odds ratio (OR) or hazard ratio (HR) were calculated using random-effects meta-analysis for the prespecified outcome. Heterogeneity was assessed using I2 statistics.
Results: Six studies met the inclusion criteria. There were 6,858 patients; 1,314 (19%) had history of AF. During a mean follow up that ranged between 4 and 8 years, 405 (30.8%) patients with AF died as compared to 1,011 (18.2%) patients without AF (OR =2.49, 95% CI: 1.85–3.35, P},
issn = {2223-3660}, url = {https://cdt.amegroups.org/article/view/13292}
}