@article{CDT15133,
author = {Mathias Hillebrand and Dietmar Koschyk and Pia ter Hark and Helke Schüler and Meike Rybczynski and Jürgen Berger and Amit Gulati and Alexander M. Bernhardt and Christian Detter and Evaldas Girdauskas and Stefan Blankenberg and Yskert von Kodolitsch},
title = {Diagnostic accuracy study of routine echocardiography for bicuspid aortic valve: a retrospective study and meta-analysis},
journal = {Cardiovascular Diagnosis and Therapy},
volume = {7},
number = {4},
year = {2017},
keywords = {},
abstract = {Background: Transthoracic echocardiography (TTE) is the standard procedure to distinguish tricuspid aortic valve (TAV) from bicuspid aortic valve (BAV). Published studies assessed the accuracy of TTE for BAV under ideal conditions. Conversely, we aimed at assessing accuracy of TTE for BAV under routine conditions.
Methods: This retrospective, cross-sectional study of 216 adults included 132 men aged 62±14 years. Of these, 108 had BAV and 108 were age-matched individuals with TAV. All diagnoses were confirmed at surgery. We assessed TTE in two patient groups. First, in the (I) group of all 216 individuals, where we assessed accuracy for BAV according to the original diagnoses as documented by the primary investigators during original TTE examination. Second, we assessed accuracy for BAV according to expert re-evaluation in (II) all 158 TTE with availability of original recordings. Third, we performed a meta-analysis of published results on the accuracy of TTE for BAV according to PRISMA standards.
Results: Sensitivity, specificity and accuracy of (I) primary investigators was 46.3%, 97.2, and 71.8% as compared to (II) expert re-evaluation with 59.7%, 93%, and 77.8%, respectively. Sensitivity was significantly higher at re-evaluation (P},
issn = {2223-3660}, url = {https://cdt.amegroups.org/article/view/15133}
}