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Ginsenoside Rb2 alleviates myocardial ischemia/reperfusion injury through IKKα lactylation regulation of macrophage polarization

   
@article{CDT154022,
	author = {Peng An and Meiqi Zhang and Mengshi Cheng and Weihua Wu and Wei Zhang and Zhenfei Yu and Rui Liu},
	title = {Ginsenoside Rb2 alleviates myocardial ischemia/reperfusion injury through IKKα lactylation regulation of macrophage polarization},
	journal = {Cardiovascular Diagnosis and Therapy},
	volume = {16},
	number = {3},
	year = {2026},
	keywords = {},
	abstract = {Myocardial ischemia/reperfusion (I/R) injury (MIRI) is a major contributor to cardiovascular morbidity, characterized by inflammatory responses and cardiomyocyte death. Ginsenoside Rb2 (Rb2), a bioactive compound from Panax ginseng, has shown potential cardioprotective effects, but its mechanisms in I/R injury remain unclear. Macrophage polarization refers to the process by which macrophages dynamically shift between pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes in response to microenvironmental signals. This study aimed to investigate whether Rb2 could participate in the progression of MIRI by regulating macrophage polarization.},
	issn = {2223-3660},	url = {https://cdt.amegroups.org/article/view/154022}
}