@article{CDT16906,
author = {Yskert von Kodolitsch and Oliver Wilson and Helke Schüler and Axel Larena-Avellaneda and Tilo Kölbel and Sabine Wipper and Fiona Rohlffs and Christian Behrendt and E. Sebastian Debus and Jens Brickwedel and Evaldas Girdauskas and Christian Detter and Alexander M. Bernhardt and Jürgen Berger and Stefan Blankenberg and Hermann Reichenspurner and Tamer Ghazy and Klaus Matschke and Ralf-Thorsten Hoffmann and Norbert Weiss and Adrian Mahlmann},
title = {Warfarin anticoagulation in acute type A aortic dissection survivors (WATAS)},
journal = {Cardiovascular Diagnosis and Therapy},
volume = {7},
number = {6},
year = {2017},
keywords = {},
abstract = {Background: Early survivors of acute type A aortic dissection (AAAD) remain at risk for late death and late aortic events. However, the frequency and long-term effects of warfarin anticoagulation on long-term outcome in post-surgical AAAD survivors have not been elucidated.
Methods: Two tertiary care centers performed a retrospective observational cohort study of warfarin anticoagulation in AAAD in 243 persons with early survival of surgical repair (WATAS). Serial postoperative tomographic imaging was available in 106 persons.
Results: A total of 88 postoperative AAAD survivors (36%) were on long-term warfarin anticoagulation. The indication for anticoagulation was a mechanical aortic prosthesis in 46 (52%), atrial fibrillation in 33 (38%), stroke in 7 (8%), and pulmonary embolism in one (1%). The indication for anticoagulation remained unclear in one person (1%). Survival and aortic event free survival were 98.3±0.01 and 98.7±0.01 at 1 year, and 76.4±0.03 and 91.8±0.02 at 5 years, respectively, with no differences irrespective of warfarin anticoagulation. Multivariate Cox regression analysis established higher age (P},
issn = {2223-3660}, url = {https://cdt.amegroups.org/article/view/16906}
}