%0 Journal Article
%T Warfarin anticoagulation in acute type A aortic dissection survivors (WATAS)
%A Kodolitsch, Yskert von
%A Wilson, Oliver
%A Schüler, Helke
%A Larena-Avellaneda, Axel
%A Kölbel, Tilo
%A Wipper, Sabine
%A Rohlffs, Fiona
%A Behrendt, Christian
%A Debus, E. Sebastian
%A Brickwedel, Jens
%A Girdauskas, Evaldas
%A Detter, Christian
%A Bernhardt, Alexander M.
%A Berger, Jürgen
%A Blankenberg, Stefan
%A Reichenspurner, Hermann
%A Ghazy, Tamer
%A Matschke, Klaus
%A Hoffmann, Ralf-Thorsten
%A Weiss, Norbert
%A Mahlmann, Adrian
%J Cardiovascular Diagnosis and Therapy
%D 2017
%B 2017
%9 
%! Warfarin anticoagulation in acute type A aortic dissection survivors (WATAS)
%K 
%X Background: Early survivors of acute type A aortic dissection (AAAD) remain at risk for late death and late aortic events. However, the frequency and long-term effects of warfarin anticoagulation on long-term outcome in post-surgical AAAD survivors have not been elucidated.   Methods: Two tertiary care centers performed a retrospective observational cohort study of warfarin anticoagulation in AAAD in 243 persons with early survival of surgical repair (WATAS). Serial postoperative tomographic imaging was available in 106 persons.   Results: A total of 88 postoperative AAAD survivors (36%) were on long-term warfarin anticoagulation. The indication for anticoagulation was a mechanical aortic prosthesis in 46 (52%), atrial fibrillation in 33 (38%), stroke in 7 (8%), and pulmonary embolism in one (1%). The indication for anticoagulation remained unclear in one person (1%). Survival and aortic event free survival were 98.3±0.01 and 98.7±0.01 at 1 year, and 76.4±0.03 and 91.8±0.02 at 5 years, respectively, with no differences irrespective of warfarin anticoagulation. Multivariate Cox regression analysis established higher age (P
%U https://cdt.amegroups.org/article/view/16906
%V 7
%N 6
%P 559-571
%@ 2223-3660