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Exercise capacity in asymptomatic patients with significant primary mitral regurgitation: independent effect of global longitudinal left ventricular strain

   
@article{CDT19691,
	author = {Amgad Mentias and Alaa Alashi and Peyman Naji and A. Marc Gillinov and L. Leonardo Rodriguez and Tomislav Mihaljevic and Rakesh M. Suri and Richard A. Grimm and Lars G. Svensson and Brian P. Griffin and Milind Y. Desai},
	title = {Exercise capacity in asymptomatic patients with significant primary mitral regurgitation: independent effect of global longitudinal left ventricular strain},
	journal = {Cardiovascular Diagnosis and Therapy},
	volume = {8},
	number = {4},
	year = {2018},
	keywords = {},
	abstract = {Background: Despite preserved left ventricular ejection fraction (LVEF), patients with significant primary mitral regurgitation (MR) often have reduced exercise capacity. In asymptomatic patients with ≥3+ primary MR undergoing rest-stress echocardiography (RSE), we sought to evaluate the incremental impact of left ventricular global longitudinal strain (LV-GLS) on exercise capacity.
Methods: A total of 660 asymptomatic patients with ≥3+ primary MR, non-dilated LV and LVEF ≥60% (mean age, 57±14 years, 66% men, body mass index or BMI 25±4 kg/m2) who underwent RSE at our center between 2001 and 2013 were included. Standard RSE data were obtained. Average resting LV-GLS was measured using Velocity Vector Imaging.
Results: Mean mitral effective regurgitant orifice, resting right ventricular systolic pressure (RVSP) and LV-GLS were 0.45±0.2 cm2, 31±12 mmHg and −21.7%±2%, respectively; 28% had flail mitral leaflet. Mean metabolic equivalents (METs) and post-stress RVSP were 9.9±3, and 46±17 mmHg; 28% achieved },
	issn = {2223-3660},	url = {https://cdt.amegroups.org/article/view/19691}
}