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Total Astragalus saponins attenuates CVB3-induced viral myocarditis through inhibiting expression of tumor necrosis factor α and Fas ligand

   
@article{CDT28599,
	author = {Yunfeng Xiao and Tianlong Liu and Xiaoling Liu and Lanbin Zheng and Dongsheng Yu and Yuanyan Zhang and Xinyu Qian and Xiaolei Liu},
	title = {Total Astragalus saponins attenuates CVB3-induced viral myocarditis through inhibiting expression of tumor necrosis factor α and Fas ligand},
	journal = {Cardiovascular Diagnosis and Therapy},
	volume = {9},
	number = {4},
	year = {2019},
	keywords = {},
	abstract = {Background: To investigate the therapeutic effect of total Astragalus saponins (AST) against viral myocarditis in animal and cell models.
Methods: Primary myocardiocytes (PMCs) were stimulated by the coxsackie B (CVB) 3 virus to prepare the cell model of viral myocarditis. Cell viability, apoptosis and the mRNA expression of C-Myc, tumor necrosis factor (TNF)-α and Fas were detected to evaluate the protective effects of AST on CVB3-induced PMC damage.
Results: AST could significantly increase survival and decrease the ratio of heart weight: body weight (P},
	issn = {2223-3660},	url = {https://cdt.amegroups.org/article/view/28599}
}