@article{CDT6706,
author = {Angelo Avogaro and Gian Paolo Fadini},
title = {Mechanisms of ectopic calcification: implications for diabetic vasculopathy},
journal = {Cardiovascular Diagnosis and Therapy},
volume = {5},
number = {5},
year = {2015},
keywords = {},
abstract = {Vascular calcification (VC) is the deposition of calcium/phosphate in the vasculature, which portends a worse clinical outcome and predicts major adverse cardiovascular events. VC is an active process initiated and regulated via a variety of molecular signalling pathways. There are mainly two types of calcifications: the media VC and the intima VC. All major risk factors for cardiovascular disease (CVD) have been linked to the presence/development of VC. Besides the risk factors, a genetic component is also operative to determine arterial calcification. Several events take place before VC is established, including inflammation, trans-differentiation of vascular cells and homing of circulating pro-calcific cells. Diabetes is an important predisposing factor for VC. Compared with non-diabetic subjects, patients with diabetes show increased VC and higher expression of bone-related proteins in the medial layer of the vessels. In this review we will highlight the mechanisms underlying vascular calcification in diabetic patients.},
issn = {2223-3660}, url = {https://cdt.amegroups.org/article/view/6706}
}