@article{CDT9687,
author = {Daniel Staub and Sasan Partovi and Thomas Zeller and Tobias Breidthardt and Max Kaech and Jasper Boeddinghaus and Christian Puelacher and Thomas Nestelberger and Markus Aschwanden and Christian Mueller},
title = {Multimarker assessment for the prediction of renal function improvement after percutaneous revascularization for renal artery stenosis},
journal = {Cardiovascular Diagnosis and Therapy},
volume = {6},
number = {3},
year = {2016},
keywords = {},
abstract = {Background: Identifying patients likely to have improved renal function after percutaneous transluminal renal angioplasty and stenting (PTRA) for renal artery stenosis (RAS) is challenging. The purpose of this study was to use a comprehensive multimarker assessment to identify those patients who would benefit most from correction of RAS.
Methods: In 127 patients with RAS and decreased renal function and/or hypertension referred for PTRA, quantification of hemodynamic cardiac stress using B-type natriuretic peptide (BNP), renal function using estimated glomerular filtration rate (eGFR), parenchymal renal damage using resistance index (RI), and systemic inflammation using C-reactive protein (CRP) were performed before intervention.
Results: Predefined renal function improvement (increase in eGFR ≥10%) at 6 months occurred in 37% of patients. Prognostic accuracy as quantified by the area under the receiver-operating characteristics curve for the ability of BNP, eGFR, RI and CRP to predict renal function improvement were 0.59 (95% CI, 0.48–0.70), 0.71 (95% CI, 0.61–0.81), 0.52 (95% CI, 0.41–0.65), and 0.56 (95% CI, 0.44–0.68), respectively. None of the possible combinations increased the accuracy provided by eGFR (lower eGFR indicated a higher likelihood for eGFR improvement after PTRA, P=ns for all). In the subgroup of 56 patients with pre-interventional eGFR },
issn = {2223-3660}, url = {https://cdt.amegroups.org/article/view/9687}
}