High-risk atherosclerotic plaque features for cardiovascular risk assessment in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain trial

Over the past decade, our understanding of coronary atherosclerosis has evolved from a paradigm dominated by coronary stenosis towards a deeper, more nuanced appreciation of coronary anatomy and physiology. Following the observation that most myocardial infarctions are caused by lesions deemed non-obstructive, there has been continued fervent search for imaging markers of plaque likely to cause adverse events.