Prof. Stephen Y. Chan, Associate Professor of Medicine, Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States (Figure 1), has been delving into the molecular mechanisms of pulmonary vascular disease and pulmonary hypertension. Through capitalizing on the emerging discipline “network medicine”, his team is putting sustained effort in the definition of the network biology of non-coding RNAs in pulmonary hypertension, the study of the molecular regulation of mitochondrial metabolism by microRNAs, and the definition of the regulation of circulating microRNAs in hypoxia and exercise.